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J Cell Physiol. 2019 Aug;234(8):12237-12248. doi: 10.1002/jcp.27965. Epub 2018 Dec 10.

Curcumin as a therapeutic candidate for multiple sclerosis: Molecular mechanisms and targets.

Author information

1
Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran.
2
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.
3
Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
4
Department of Toxicology & Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran.
5
Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
6
Clinical Pharmacy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.
7
Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.
8
Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.
9
Diabetes Research Center, Qatar Biomedical Research Institute, Doha, Qatar.
10
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
11
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
12
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Multiple sclerosis (MS) is a disease that has shown a considerable increase in prevalence in recent centuries. Current knowledge about its etiology is incomplete, and therefore it cannot be managed optimally utilizing targeted therapeutic regimens at each stage of the disease. MS progresses in different stages, beginning with a cascade of inflammation. The pivotal spark to initiate this cascade seems to be the migration of Th17 into the central nervous system across the blood-brain barrier (BBB) through the disrupted tight junctions. Coupling of interleukin (IL)-17 and IL-22 to their receptors in the BBB layer facilitates this migration. Subsequently, axon degeneration and the various manifestations of nerve-muscle disorders appear. Curcumin, a major component of turmeric, is derived from Curcuma longa, which belongs to the Zingiberaceae family. Numerous properties of curcumin have been identified recently, some of which can be effective in the treatment of MS, particularly the anti-inflammatory properties via inhibition of secretion of proinflammatory cytokines. In this paper, we will review the various properties and key effects of curcumin for the treatment of MS.

KEYWORDS:

curcumin; immune system; inflammation; multiple sclerosis (MS)

PMID:
30536381
DOI:
10.1002/jcp.27965

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