Format

Send to

Choose Destination
Neural Regen Res. 2019 Feb;14(2):201-205. doi: 10.4103/1673-5374.244775.

Neural plasticity and adult neurogenesis: the deep biology perspective.

Author information

1
Laboratory of Neuroscience "R. Levi-Montalcini", Dept. of Biotechnology and Biosciences; SYSBIO Centre of Systems Biology; NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milano, Italy.
2
Laboratory of Morphology of Neuronal Network, Department of Public Medicine, University of Campania "Luigi Vanvitelli", Napoli, Italy.
3
SYSBIO Centre of Systems Biology; NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milano, Italy.
4
SYSBIO Centre of Systems Biology, University of Milano-Bicocca, Milano; Laboratory of Morphology of Neuronal Network, Department of Public Medicine, University of Campania "Luigi Vanvitelli", Napoli, Italy.
5
Synthetic Systems Biology and Nuclear Organization, University of Amsterdam, Molecular Cell Physiology, VU University Amsterdam, and Infrastructure Systems Biology at NL (ISBE.NL), Amsterdam, NL, and Systems Biology, School for Chemical Engineering and Analytical Science, University of Manchester, UK.

Abstract

The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology.

KEYWORDS:

adult brain; deep biology; differentiation; energy homeostasis; mitochondria; nerve growth factor; neurogenesis; neuron; neuroregeneration; systems biology

PMID:
30530998
PMCID:
PMC6301164
[Available on 2019-02-01]
DOI:
10.4103/1673-5374.244775
Free full text

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd
Loading ...
Support Center