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J Investig Med. 2019 Mar;67(3):663-668. doi: 10.1136/jim-2018-000869. Epub 2018 Dec 9.

Association of triglyceride to HDL cholesterol ratio with cardiometabolic outcomes.

Author information

1
Stanford University School of Medicine, Stanford, California, USA.
2
Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, California, USA.
3
Stanford University Department of Medicine, Stanford, California, USA.

Abstract

Electronic medical records (EMRs) offer a potential opportunity to identify patients at high risk for cardiometabolic disease, which encompasses type 2 diabetes and cardiovascular disease (CVD). The objective of this retrospective cohort study is to use information gathered from EMR to investigate the association between triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) and cardiometabolic outcomes in a general population of subjects over 50 years of age during a follow-up period of 8-9 years. TG/HDL-C was recorded for each of 1428 subjects in 2008, and diagnoses of type 2 diabetes and CVD were recorded through chart review until 2017. Cox proportional hazards models controlling for demographic characteristics and other risk factors demonstrated that high TG/HDL-C (>2.5 in women or >3.5 in men) was significantly associated with increased incidence of type 2 diabetes (HR 1.66; 95% CI 1.07 to 2.57; p=0.0230). There was also a suggested association between high TG/HDL-C and incidence of CVD (HR 1.51; 95% CI 0.98 to 2.35; p=0.0628). These findings suggest that using TG/HDL-C, which can be easily calculated from data in an EMR, should be another tool used in identifying patients at high cardiometabolic risk.

KEYWORDS:

cardiovascular disease

PMID:
30530527
DOI:
10.1136/jim-2018-000869

Conflict of interest statement

Competing interests: None declared.

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