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Eur J Dermatol. 2018 Oct 1;28(5):597-605. doi: 10.1684/ejd.2018.3403.

The genetics of cutaneous squamous cell carcinogenesis.

Author information

1
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup) - Cancer Signaling and Metabolism, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal, Medical Faculty, University of Porto, Al. Prof. Hernâni Monteiro, 4200 Porto, Portugal, Dermatology Department, Centro Hospitalar Vila Nova de Gaia, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia, Portugal.
2
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup) - Cancer Signaling and Metabolism, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal, Medical Faculty, University of Porto, Al. Prof. Hernâni Monteiro, 4200 Porto, Portugal, Department of Pathology, Medical Faculty of Porto University, Porto, Portugal, Department of Pathology, Hospital de S. João, Al. Prof. Hernâni Monteiro, 4200 Porto, Portugal.
3
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup) - Cancer Signaling and Metabolism, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal, Medical Faculty, University of Porto, Al. Prof. Hernâni Monteiro, 4200 Porto, Portugal, Department of Pathology, Medical Faculty of Porto University, Porto, Portugal.

Abstract

In this review, the current knowledge of cutaneous squamous cell carcinogenesis (cSCC) is outlined based on an appraisal of the different features of cSCC, with particular emphasis on genetic alterations underlying aetiopathogenesis. When appropriate, diagnostic and/or prognostic biomarkers for cSCC are also considered. This review is intended to aid future investigation into the molecular characterization of cSCC.

KEYWORDS:

cSCC; carcinogenesis; cutaneous squamous cell carcinoma; genetics

PMID:
30530431
DOI:
10.1684/ejd.2018.3403
[Indexed for MEDLINE]

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