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Environ Pollut. 2019 Mar;246:107-113. doi: 10.1016/j.envpol.2018.11.110. Epub 2018 Dec 1.

Association of serum levels of 4-tertiary-octylphenol with cardiovascular risk factors and carotid intima-media thickness in adolescents and young adults.

Author information

1
Department of Internal Medicine, En Chu Kong Hospital, New Taipei City, 237, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, 242, Taiwan.
2
Department of Statistics, National Taipei University, New Taipei City, 237, Taiwan.
3
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, 10020, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, Taipei, 10020, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, 10002, Taiwan.
4
Department of Health Services Administration, College of Public Health, China Medical University, Taichung, 404, Taiwan.
5
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, 10020, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, 10002, Taiwan; Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei, 10002, Taiwan. Electronic address: tachensu@gmail.com.

Abstract

In the family of alkylphenolic compounds, 4-tertiary-Octylphenol (4-t-OP) is extensively used in many products. In animal and in vitro studies, 4-t-OP exposure has been linked to cardiovascular disease (CVD) risk factors; however, there are no previous human epidemiological studies. In this study, 886 subjects were recruited from a cohort of Taiwanese adolescents and young adults to study the relationship between serum levels of 4-t-OP, CVD risk factors, and common carotid artery intima-media thickness (CIMT). The geometric mean (SD) 4-t-OP concentration was 32.52 (1.71) ng/mL. We found that serum levels of 4-t-OP were negatively associated with markers of glucose homeostasis (insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β)), z score of body mass index (BMI z score) and CIMT but were positively associated with lipid profiles (high density lipoprotein cholesterol (HDL-C), Apolipoprotein A1). A one-unit elevation in natural log-transformed 4-t-OP (ng/mL) was negatively correlated with CIMT (mm) (β = -0.029, SE = 0.003, P < 0.001) in multiple linear regression analyses. The relationship between 4-t-OP and CIMT remained the same in all subgroups or if bisphenol A (BPA) was considered a covariate. In this study, we observed that higher levels of 4-t-OP levels were negatively correlated with markers of glucose homeostasis, BMI z score, and CIMT; positively correlated with lipid profiles (HDL-C and apolipoprotein A) in this cohort. Future research on exposure to 4-t-OP and CVD risk factors is warranted.

KEYWORDS:

4-Tertiary-Octylphenol (4-t-OP); Bisphenol A (BPA); Cardiovascular disease risk factors; Common carotid artery intima-media thickness; Homeostasis model assessment of insulin resistance (HOMA-IR)

PMID:
30529934
DOI:
10.1016/j.envpol.2018.11.110
[Indexed for MEDLINE]

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