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Nanomedicine. 2019 Feb;16:106-125. doi: 10.1016/j.nano.2018.11.013. Epub 2018 Dec 7.

Genotoxicity of amorphous silica nanoparticles: Status and prospects.

Author information

1
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, United States; Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, Utah, United States.
2
Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, Utah, United States; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, United States.
3
Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, United States.
4
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, United States; Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, Utah, United States; Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States. Electronic address: hamid.ghandehari@utah.edu.

Abstract

Amorphous silica nanoparticles (SNPs) are widely used in biomedical applications and consumer products. Little is known, however, about their genotoxicity and potential to induce gene expression regulation. Despite recent efforts to study the underlying mechanisms of genotoxicity of SNPs, inconsistent results create a challenge. A variety of factors determine particle-cell interactions and underlying mechanisms. Further, high-throughput studies are required to carefully assess the impact of silica nanoparticle physicochemical properties on induction of genotoxic response in different cell lines and animal models. In this article, we review the strategies available for evaluation of genotoxicity of nanoparticles (NPs), survey current status of silica nanoparticle gene alteration and genotoxicity, discuss particle-mediated inflammation as a contributing factor to genotoxicity, identify existing gaps and suggest future directions for this research.

KEYWORDS:

Gene expression profile; Genotoxicity; Inflammation; Silica nanoparticles; Structure–activity relationship

PMID:
30529789
PMCID:
PMC6455809
[Available on 2020-02-01]
DOI:
10.1016/j.nano.2018.11.013
[Indexed for MEDLINE]

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