Format

Send to

Choose Destination
Adv Drug Deliv Rev. 2018 Dec 4. pii: S0169-409X(18)30301-6. doi: 10.1016/j.addr.2018.11.006. [Epub ahead of print]

Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges.

Author information

1
Department of Physics, Chalmers University of Technology, Gothenburg SE-412 96, Sweden.
2
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia, Mawson Lakes Campus, Mawson Lakes 5095, Australia.
3
Drug Product Development, Janssen R&D, Johnson & Johnson, Turnhoutseweg 30, Beerse 2340, Belgium; Department of Science and Environment, Roskilde University, Roskilde 4000, Denmark.
4
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia, Mawson Lakes Campus, Mawson Lakes 5095, Australia. Electronic address: clive.prestidge@unisa.edu.au.

Abstract

Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a solubilised state during gastrointestinal transit. However, the promising biopharmaceutical benefits of liquid lipid formulations has not translated into widespread commercial success, due to their susceptibility to long term storage and in vivo precipitation issues. One strategy that has emerged to overcome such limitations, is to combine the solubilisation and dissolution enhancing properties of lipids with the stabilising effects of solid carrier materials. The development of intelligent hybrid drug formulations has presented new opportunities to harness the potential of emulsified lipids in optimising oral bioavailability for lipophilic therapeutics. Specific emphasis of this review is placed on the impact of solidification approaches and excipients on the biopharmaceutical performance of self-emulsifying lipids, with findings highlighting the key design considerations that should be implemented when developing hybrid lipid-based formulations.

KEYWORDS:

Bioavailability; Lipid-based drug delivery system; Lipid-based formulation; Oral delivery; Pharmacokinetics; Poorly water-soluble drugs; SEDDS; Self-emulsifying lipids; Solidification

PMID:
30529138
DOI:
10.1016/j.addr.2018.11.006

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center