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Eur J Cell Biol. 2018 Nov 30. pii: S0171-9335(18)30181-X. doi: 10.1016/j.ejcb.2018.11.005. [Epub ahead of print]

Adipose tissue, angiogenesis and angio-MIR under physiological and pathological conditions.

Author information

1
Department of Surgical, Oncological and Oral Sciences, Section of Plastic and Reconstructive Surgery, University of Palermo, 90127 Palermo, Italy; Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90127 Palermo, Italy. Electronic address: annabarbara.distefano@gmail.com.
2
Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90127 Palermo, Italy. Electronic address: danielamassi87@gmail.com.
3
Department of Surgical, Oncological and Oral Sciences, Section of Plastic and Reconstructive Surgery, University of Palermo, 90127 Palermo, Italy; Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90127 Palermo, Italy. Electronic address: federica.grisafi@unipa.it.
4
Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90127 Palermo, Italy. Electronic address: martacastiglia@gmail.com.
5
Department of Surgical, Oncological and Oral Sciences, Section of Plastic and Reconstructive Surgery, University of Palermo, 90127 Palermo, Italy. Electronic address: francescatoia@gmail.com.
6
Department of Surgical, Oncological and Oral Sciences, Section of Plastic and Reconstructive Surgery, University of Palermo, 90127 Palermo, Italy. Electronic address: luigi.montesano@unipa.it.
7
Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90127 Palermo, Italy. Electronic address: antonio.russo@usa.net.
8
Department of Surgical, Oncological and Oral Sciences, Section of Plastic and Reconstructive Surgery, University of Palermo, 90127 Palermo, Italy. Electronic address: francesco.moschella@unipa.it.
9
Department of Surgical, Oncological and Oral Sciences, Section of Plastic and Reconstructive Surgery, University of Palermo, 90127 Palermo, Italy. Electronic address: adriana.cordova@unipa.it.

Abstract

Angiogenesis is a crucial process for the maintenance of normal tissue physiology and it is involved in tissue remodeling and regeneration. This process is essential for adipose tissue maintenance. The adipose tissue is composed by different cell types including stromal vascular cells as well as adipose stem cells (ASCs). In particular, ASCs are multipotent somatic stem cells that are able to differentiate and secrete several growth factors; they are recently emerging as a new cell reservoir for novel therapies and strategies in many diseases. Several studies suggest that ASCs have peculiar properties and participate in different disease-related processes such as angiogenesis. Furthermore, pathological expansion of adipose tissue brings to hypoxia, a major condition of unhealthy angiogenesis. Recent evidences have shown that microRNAs (miRNAs) play a crucial role also on ASCs as they take part in stemness maintenance, proliferation, and differentiation. It has been suggested that some miRNAs (MIR126, MIR31, MIR221 MIR222, MIR17-92 cluster, MIR30, MIR100 and MIR486) are directly involved in the angiogenic process by controlling multiple genes involved in this pathway. With the present review, we aim at providing an updated summary of the importance of adipose tissue under physiological and pathological conditions and of its relationship with neovascularization process. In particular, we report an overview of the most important miRNAs involved in angiogenesis focusing on ASCs. Hopefully the data presented will bring benefit in developing new therapeutic strategies.

KEYWORDS:

Adipose stem cells; Angiogenesis; Endothelial cells; miRNAs

PMID:
30527802
DOI:
10.1016/j.ejcb.2018.11.005

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