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Neuroimage Clin. 2019;21:101598. doi: 10.1016/j.nicl.2018.11.008. Epub 2018 Nov 13.

Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders.

Author information

1
Copenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Rigshospitalet, 6233, Blegdamsvej 9, 2100 Copenhagen, Denmark; Danish Research Centre of Magnetic Resonance, Copenhagen University Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark.
2
Copenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Rigshospitalet, 6233, Blegdamsvej 9, 2100 Copenhagen, Denmark.
3
Department of Psychiatry, University of Illinois at Chicago, 1747 Roosevelt Rd, Chicago, IL 60608, USA.
4
University of California Davis, 135 Young Hall, One Shields Avenue, CA 95616, USA.
5
Centre for Psychiatry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
6
Danish Research Centre of Magnetic Resonance, Copenhagen University Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital, Bispebjerg, University of Copenhagen, Hvidovre Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark.
7
Copenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Rigshospitalet, 6233, Blegdamsvej 9, 2100 Copenhagen, Denmark; Department of Psychology, University of Copenhagen, Øster Farimagsgade 2A, 1353 København K, Denmark. Electronic address: kamilla@miskowiak.dk.

Abstract

PURPOSE:

We investigated the neural correlates of emotion regulation and -reactivity in adult unaffected monozygotic twins with a co-twin history of unipolar or bipolar disorder (high-risk), remitted or partially remitted twins with a personal history of unipolar or bipolar disorder (affected) and twins with no personal or first-degree family history of unipolar or bipolar disorder (low-risk).

METHODS:

We assessed 37 high-risk, 56 affected and 28 low-risk participants. Participants viewed unpleasant and neutral pictures during functional magnetic resonance imaging and were instructed to down-regulate their emotional response through reappraisal or mental imagery, as well as to maintain the elicited emotion.

RESULTS:

After adjusting for subsyndromal depressive symptoms, bilateral supplementary motor areas, posterior dorsal anterior cingulate cortices and the left frontal eye field showed less activity during reappraisal of unpleasant pictures in high-risk than low-risk participants. Notably, affected participants did not differ from high-risk or low-risk participants in neural response during reappraisal. There were no group differences in ventrolateral prefrontal cortex seed based functional connectivity during reappraisal or neural response during mental imagery or emotional reactivity.

CONCLUSION:

Lesser response in dorsal midline areas might reflect familial risk related abnormalities during down regulation of emotional reactivity through reappraisal.

KEYWORDS:

Cognitive neuroscience; Endophenotypes; Magnetic resonance imaging; Monozygotic twins; Mood disorder

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