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Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):23-29. doi: 10.1016/j.numecd.2018.09.011. Epub 2018 Oct 20.

Circulating Pro-Neurotensin in gestational diabetes mellitus.

Author information

1
University of Leipzig, Department of Endocrinology and Nephrology, 04103, Leipzig, Germany.
2
University of Leipzig, Department of Endocrinology and Nephrology, 04103, Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103, Leipzig, Germany.
3
Leipzig University Medical Center, IFB AdiposityDiseases, 04103, Leipzig, Germany.
4
University of Leipzig, Institute of Laboratory Medicine, 04103, Leipzig, Germany.
5
University of Leipzig, Department of Endocrinology and Nephrology, 04103, Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103, Leipzig, Germany; Justus-Liebig-University, Institute of Nutritional Science, 35390, Giessen, Germany.
6
University of Leipzig, Department of Endocrinology and Nephrology, 04103, Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103, Leipzig, Germany. Electronic address: Thomas.ebert@medizin.uni-leipzig.de.

Abstract

BACKGROUND AND AIMS:

Pro-Neurotensin (NT), a stable surrogate parameter of NT, has recently been introduced as a peptide predicting the development of obesity, diabetes mellitus, cardiovascular diseases, and cardiovascular mortality. However, regulation of Pro-NT in gestational diabetes mellitus (GDM) remains uninvestigated.

METHODS AND RESULTS:

Pro-NT was quantified in 74 women with GDM, 74 healthy, gestational age-matched, pregnant controls, as well as in a second cohort comprising of 74 healthy, non-pregnant control women, using a chemiluminometric sandwich immunoassay. Pro-NT was correlated to measures of obesity, hypertension, glucose and lipid metabolism, renal function, and inflammation. Mean ± standard deviation of circulating Pro-NT levels were not significantly different in women with GDM (100.2 ± 75.7 pmol/l) as compared to healthy, pregnant controls (103.2 ± 37.4 pmol/l) and healthy, non-pregnant female controls (105.9 ± 38.9 pmol/l) (p = 0.661). Homeostasis model assessment of insulin resistance (HOMA-IR) and creatinine positively correlated with serum Pro-NT in multivariate regression analysis. In contrast, free fatty acids (FFA) were inversely correlated with circulating Pro-NT. Results sustained adjustment for pregnancy status.

CONCLUSIONS:

Circulating Pro-NT is not independently associated with GDM, but is with HOMA-IR, creatinine, and FFA even after adjustment for pregnancy status.

KEYWORDS:

Gestational diabetes mellitus; Insulin resistance; Neurotensin; Pregnancy; Pro-Neurotensin

PMID:
30527352
DOI:
10.1016/j.numecd.2018.09.011
[Indexed for MEDLINE]

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