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Mini Rev Med Chem. 2019;19(6):450-464. doi: 10.2174/1389557519666181210162003.

Hybrid Molecules Development: A Versatile Landscape for the Control of Antifungal Drug Resistance: A Review.

Author information

1
Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, Johannesburg, South Africa.
2
Department of Chemistry, University of Fort Hare, Alice Campus, Alice, South Africa.

Abstract

Hybrid molecule approach of drug design has become popular due to advantages such as delayed resistance, reduced toxicity, ease of treatment of co-infection and lower cost of preclinical evaluation. Antifungal drugs currently available for the treatment of fungal diseases suffer a major side effect of drug resistance. Hybrid drugs development is one of the approaches that has been employed to control microbial resistance. Their antifungal activity is influenced by their design. This review is focused on hybrid molecules exhibiting antifungal properties to guide scientists in search of more efficient drugs for the treatment of fungal diseases.

KEYWORDS:

Heterocyclic compounds; antifungal; co-infection; fungal diseases; hybrid compounds; preclinical evaluation.

[Indexed for MEDLINE]

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