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Nat Prod Res. 2018 Dec 9:1-5. doi: 10.1080/14786419.2018.1511553. [Epub ahead of print]

A new phenolic glycoside from the Idesia polycarpa Maxim. leaves.

Huang L1,2, Peng T2,3, Li Y1,2, He Y2,3, Wang L2,3, Zhang S2,3, Sun Y2,3, Chen F1,2,3, Tang L1,2,3.

Author information

1
a Institute of New Energy and Low-Carbon Technology, Sichuan University , Chengdu , P.R. China.
2
b National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application , Chengdu , P.R. China.
3
c Key Laboratory of Bio-resources and Eco-environment of Ministry of Education , College of Life Sciences, Sichuan University , Chengdu , P.R. China.

Abstract

Phytochemical investigation on the ethyl acetate extract of Idesia polycarpa Maxim. Leaves led to the isolation of four phenolic glycoside isomers (1-4). Compound 2 appeared to be new reported phenolic glycoside, while compound 1 was the first time isolated from the titled species. Their structures were established by IR, UV, HRESI-MS and 1D and 2D NMR spectroscopies analysis and comparison of spectral data with previously reported data. The compounds 3 and 4 showed stronger activity of scavenging the DPPH free radical than the other two compounds, while the compounds 1 and 2 showed a significant activity of scavenging the ABTS free radical. Compounds 2 and 4 exhibited stronger cytotoxicity against HepG2 cell lines compared to compounds 1 and 3. Moreover, compound 3 presented the highest cytotoxicity against MCF cell lines with IC50 value of 37.17 ± 0.26 μg/mL than compounds 1, 2 and 4.

KEYWORDS:

Idesia polycarpa Maxim.; antioxidant; cytotoxicity; phenolic glycoside isomers

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