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Annu Rev Clin Psychol. 2019 May 7;15:285-316. doi: 10.1146/annurev-clinpsy-021815-093423. Epub 2018 Dec 10.

Mindfulness Meditation and Psychopathology.

Wielgosz J1,2,3, Goldberg SB1,4, Kral TRA1,5,6, Dunne JD1,7, Davidson RJ1,5,6,8.

Author information

1
Center for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin 53703, USA; email: wielgosz@wisc.edu , sbgoldberg@wisc.edu , kral@wisc.edu , jddunne@wisc.edu , rjdavids@wisc.edu.
2
Sierra Pacific MIRECC, VA Palo Alto Health Care System, Palo Alto, California 94304, USA.
3
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California 94304, USA.
4
Department of Counseling Psychology, University of Wisconsin-Madison, Madison, Wisconsin 53703, USA.
5
Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, Wisconsin 53703, USA.
6
Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin 53703, USA.
7
Department of Asian Languages and Cultures, University of Wisconsin-Madison, Madison, Wisconsin 53703, USA.
8
Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53703, USA.

Abstract

Mindfulness meditation is increasingly incorporated into mental health interventions, and theoretical concepts associated with it have influenced basic research on psychopathology. Here, we review the current understanding of mindfulness meditation through the lens of clinical neuroscience, outlining the core capacities targeted by mindfulness meditation and mapping them onto cognitive and affective constructs of the Research Domain Criteria matrix proposed by the National Institute of Mental Health. We review efficacious applications of mindfulness meditation to specific domains of psychopathology including depression, anxiety, chronic pain, and substance abuse, as well as emerging efforts related to attention disorders, traumatic stress, dysregulated eating, and serious mental illness. Priorities for future research include pinpointing mechanisms, refining methodology, and improving implementation. Mindfulness meditation is a promising basis for interventions, with particular potential relevance to psychiatric comorbidity. The successes and challenges of mindfulness meditation research are instructive for broader interactions between contemplative traditions and clinical psychological science.

KEYWORDS:

RDoC; meditation; mindfulness; neuroscience; psychopathology

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