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Mol Cell Oncol. 2018 Sep 20;5(6):e1516452. doi: 10.1080/23723556.2018.1516452. eCollection 2018.

Controlling the mitochondrial antisense - role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance.

Author information

1
Laboratory of RNA Biology and Functional Genomics, Institute of Biochemistry and Biophysics Polish Academy of Sciences, Warsaw, Poland.
2
Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, Warsaw, Poland.
3
Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw, Warsaw, Poland.

Abstract

Transcription of the human mitochondrial genome produces a vast amount of non-coding antisense RNAs. These RNA species can form G-quadraplexes (G4), which affect their decay. We found that the mitochondrial degradosome, a complex of RNA helicase SUPV3L1 (best known as SUV3) and the ribonuclease PNPT1 (also known as PNPase), together with G4-melting protein GRSF1, is a key player in restricting antisense mtRNAs.

KEYWORDS:

G-quadraplexes; G4; GRSF1; PNPase; RNA surveillance; SUV3; mitochondrial RNA

PMID:
30525095
PMCID:
PMC6276855
[Available on 2019-09-20]
DOI:
10.1080/23723556.2018.1516452

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