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J Cancer Res Clin Oncol. 2019 Mar;145(3):609-613. doi: 10.1007/s00432-018-2812-4. Epub 2018 Dec 6.

Effect of the botanical formula LCS101 on the anti-cancer effects of radiation therapy.

Author information

1
Tal Center for Integrative Oncology, Institute of Oncology, Sheba Medical Center, Tel Hashomer, Israel.
2
Tal Center for Integrative Oncology, Institute of Oncology, Sheba Medical Center, Tel Hashomer, Israel. yair@tcm.org.il.
3
Institute of Oncology, Sheba Medical Center, Tel Hashomer, Israel.

Abstract

BACKGROUND AND PURPOSE:

The botanical formula LCS101 has been shown in clinical research to reduce chemotherapy-induced toxicities. In pre-clinical research, the formula demonstrated selective anti-cancer effects, in part as a result of radical oxygen species (ROS) activity of the botanical components. The present study examined the interaction between LCS101 and radiation therapy on cancer cell lines.

METHODS:

Incremental doses of LCS101 were added to breast adenocarcinoma (MCF7), prostate (DU145), transitional cell bladder carcinoma (T24), pancreatic epithelioid carcinoma (PANC-1), and osteosarcoma (U20S) cell lines 4 h after single-dose irradiation (range 0.5-4 Gy). Cell viability was tested using sulforhodamine B (SRB) assay after 1 week, with ROS activity examined using 1 mM of the ROS scavenger sodium pyruvate (ROS scavenger), testing cell viability with an SRB assay.

RESULTS:

The addition of LCS101 to MCF7 (breast) and DU-145 (prostate) cancer cell lines resulted in a dose-dependent increase in the antiproliferative effects of radiation treatment. The addition of pyruvate inhibited radiation-induced cell death in all of the cell lines treated with LCS101.

CONCLUSIONS:

The addition of the botanical formula LCS101 to irradiated cancer cells results in an apparent additive effect, most likely through a ROS-mediated mechanism. These findings support the use of LCS101 by patients undergoing radiation therapy, for both its clinical as well as anti-cancer effects.

KEYWORDS:

Botanical formula; Cancer; LCS101; Radiation therapy; Radical oxygen species

PMID:
30523409
DOI:
10.1007/s00432-018-2812-4
[Indexed for MEDLINE]

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