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Lipids Health Dis. 2018 Dec 6;17(1):276. doi: 10.1186/s12944-018-0910-6.

Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats.

An Y1, Li Y1, Wang X2, Chen Z3,4, Xu H1, Wu L1,5, Li S1, Wang C1, Luan W1, Wang X1, Liu M1,6, Tang X7, Yu L8.

Author information

1
Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin University, Changchun, 130062, China.
2
Key Lab for New Drugs Research of TCM in Shenzhen, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, China.
3
West China School of Public Health, Sichuan University, Chengdu, 610041, Sichuan, China.
4
Shenzhen Nanshan Center for Disease Control and prevention, Shenzhen, 518054, Guangdong, China.
5
College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163000, China.
6
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou, 225009, China.
7
Key Lab for New Drugs Research of TCM in Shenzhen, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, China. tangxd@tsinghua-sz.org.
8
Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin University, Changchun, 130062, China. yu_lu@jlu.edu.cn.

Abstract

BACKGROUND:

An increasing number of studies have shown that obesity is the key etiological agent of cardiovascular diseases, nonalcoholic fatty liver disease, type 2 diabetes and several kinds of cancer and that gut microbiota change was one of the reasons suffering from obesity. At present, the gut microbiota has gained increased attention as a potential energy metabolism organ. Our recent study reported that cordycepin, a major bioactive component separated from Cordyceps militaris, prevented body weight gain in mice fed a high-fat diet directly acting to adipocytes, however, the effect of cordycepin regulating gut microbiota keeps unknown.

METHODS:

In this research, we synthesized cordycepin (3-deoxyadenosine) by chemical methods and verified that cordycepin reduces body weight gain and fat accumulation around the epididymis and the kidneys of rats fed a high-fat diet. Furthermore, we used high-throughput sequencing on a MiSeq Illumina platform to test the species of intestinal bacteria in high-fat-diet-induced obese rats.

RESULTS:

We found that cordycepin modifies the relative abundance of intestinal bacteria in high-fat-diet-induced obese rats. However, cordycepin did not alter the variety of bacteria in the intestine. Cordycepin treatment dramatically reversed the relative abundance of two dominant bacterial phyla (Bacteroidetes and Firmicutes) in the high-fat-diet-induced obese rats, resulting in abundance similar to that of the chow diet group.

CONCLUSION:

Our study suggests that cordycepin can reduce body weight and microbiome done by cordycepin seems be a result among its mechanisms of obesity reduction.

KEYWORDS:

Body weight; Cordycepin; Fat; Gut microbiota; Obesity

PMID:
30522511
PMCID:
PMC6284310
DOI:
10.1186/s12944-018-0910-6
[Indexed for MEDLINE]
Free PMC Article

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