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Br J Clin Pharmacol. 2019 Mar;85(3):492-500. doi: 10.1111/bcp.13830. Epub 2019 Jan 11.

Antibiotic allergy labels in hospitalized and critically ill adults: A review of current impacts of inaccurate labelling.

Author information

1
Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.
2
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, VIC, Australia.
3
Department of Pharmacy, Austin Health, Heidelberg, VIC, Australia.
4
Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
5
The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Abstract

Antibiotic allergy labels (AALs) are reported by approximately 20% of hospitalized patients, yet over 85% will be negative on formal allergy testing. Hospitalized patients with an AAL have inferior patient outcomes, increased colonization with multidrug-resistant organisms and frequently receive inappropriate antimicrobials. Hospitalized populations have been well studied but, to date, the impact of AALs on patients with critical illness remains less well defined. We review the prevalence and impact of AALs on hospitalized patients, including those in in critical care.

KEYWORDS:

acute care; antimicrobial allergy; antimicrobial stewardship; penicillin allergy; skin testing

PMID:
30521088
PMCID:
PMC6379213
[Available on 2020-03-01]
DOI:
10.1111/bcp.13830

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