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Am J Med Genet. 1988 May-Jun;30(1-2):377-92.

A controlled trial of stimulant medication in children with the fragile X syndrome.

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Child Development Unit, The Children's Hospital, Denver, Colorado 80218.


Attentional deficits and hyperactivity frequently are major problems for fra(X) boys. This study evaluated the effectiveness of 2 stimulant medications, methylphenidate and dextroamphetamine compared to placebo in 15 children (13 males, 2 females) with the fra(X) syndrome. A double-blind crossover design was used with outcome measures which included parent and teacher behavior checklists, a controlled observation period, continuous performance tasks and an actometer measure of movement. When the children were treated with methylphenidate only, improvement was seen in socialization skills and attention span according to teacher checklists. Ten children were clinically considered responders and treatment was continued after the study was completed.

[Indexed for MEDLINE]

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