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Neuroradiology. 2019 Feb;61(2):175-182. doi: 10.1007/s00234-018-2139-5. Epub 2018 Dec 5.

Correlations between cervical spinal cord magnetic resonance diffusion tensor and diffusion kurtosis imaging metrics and motor performance in patients with chronic ischemic brain lesions of the corticospinal tract.

Author information

1
ITAB-Institute of Advanced Biomedical Technologies, University "G. D'Annunzio" Chieti-Pescara, Chieti, Italy. v.panara@rad.unich.it.
2
Department of Neuroscience, Imaging and Clinical Sciences, University "G. D'Annunzio" Chieti-Pescara, Via dei Vestini, 31 66100, Chieti, CH, Italy. v.panara@rad.unich.it.
3
Department of Neuroscience, Imaging and Clinical Sciences, University "G. D'Annunzio" Chieti-Pescara, Via dei Vestini, 31 66100, Chieti, CH, Italy.
4
ITAB-Institute of Advanced Biomedical Technologies, University "G. D'Annunzio" Chieti-Pescara, Chieti, Italy.

Abstract

PURPOSE:

To investigate modifications of Magnetic Resonance Diffusion Tensor Imaging (DTI) and Diffusion Kurtosis Imaging (DKI) metrics in lateral white matter (WM) bundles of the cervical spinal cord in patients with previous stroke in the vascular territory of the middle cerebral artery (MCA).

METHODS:

Twenty consecutive patients with a previous ischemic stroke of the MCA territory and a varying degree of upper motor impairment were enrolled. DKI was centered at the C3C4 and C5C6 intervertebral level.

RESULTS:

The fractional anisotropy (FA) values in C3C4 and C5C6 were found to be significantly lower in the lateral WM bundles contralateral to the ischemic lesion and thus, in the WM bundle including the affected corticospinal tract (CST) (p = 0.005 and p = 0.008, respectively), as well as mean kurtosis (MK) and axonal water fraction (AWF) values (p = 0.004 and p = 0.04. respectively). FA values correlated significantly with the Global Motor Index (GMI) both for C3C4 (ρ = 0.61, p = 0.004) and C5C6 (ρ = 0.69, p = 0.002). At C3C4, AWF correlated significantly with GMI (ρ = 0.54, p = 0.03). No correlations were found between lateral WM bundle volumes and GMI.

CONCLUSION:

A reduction of anisotropy and microstructural complexity in the affected lateral WM bundle of the cervical spinal cord was observed in patients with previous ischemic stroke involving the CST. The correlations between these metrics and motor performance were statistically significant.

KEYWORDS:

Diffusion kurtosis imaging; Diffusion tensor imaging; Spinal cord; Stroke

PMID:
30519889
DOI:
10.1007/s00234-018-2139-5
[Indexed for MEDLINE]

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