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J Autism Dev Disord. 2019 Apr;49(4):1455-1474. doi: 10.1007/s10803-018-3834-0.

Autism Spectrum Disorder: Incidence and Time Trends Over Two Decades in a Population-Based Birth Cohort.

Author information

1
Geisinger Autism & Developmental Medicine Institute, 120 Hamm Drive Suite 2, Lewisburg, PA, 17837, USA. smyers1@geisinger.edu.
2
Meyer Center for Developmental Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
3
Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
4
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
5
Division of Speech Pathology, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
6
Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Abstract

We retrospectively identified autism spectrum disorder (ASD) incident cases among 31,220 individuals in a population-based birth cohort based on signs and symptoms uniformly abstracted from medical and educational records. Inclusive and narrow research definitions of ASD (ASD-RI and ASD-RN, respectively) were explored, along with clinical diagnoses of ASD (ASD-C) obtained from the records. The incidence of ASD-RI, ASD-RN, and ASD-C increased significantly from 1985 to 1998, then ASD-RI and ASD-RN plateaued while the rate of ASD-C continued to increase during 1998-2004. The rising incidence of research-defined ASD may reflect improved recognition and documentation of ASD signs and symptoms. Although the frequency of threshold ASD symptoms stabilized, the rate of ASD-C continued to increase, narrowing the gap between clinical ascertainment and symptom documentation.

KEYWORDS:

Autism spectrum disorder; Epidemiology; Incidence; Time trends

PMID:
30519787
PMCID:
PMC6594832
[Available on 2020-04-01]
DOI:
10.1007/s10803-018-3834-0
[Indexed for MEDLINE]

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