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Transl Vis Sci Technol. 2018 Nov 30;7(6):13. doi: 10.1167/tvst.7.6.13. eCollection 2018 Nov.

Evaluation of RETICs Glaucoma Diagnostic Calculators in Preperimetric Glaucoma.

Author information

1
Department of Ophthalmology, Clínica Universidad de Navarra, Medical School, University of Navarra, Pamplona, Spain.
2
Institut Catalá de Retina, Universitat Internacional de Catalunya, Barcelona, Spain.
3
Unidad de Estadística, Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.

Abstract

Purpose:

To evaluate two glaucoma diagnostic calculators (GDC) in a group of eyes with preperimetric glaucoma (PPG).

Methods:

All eyes (n = 265) included in this study had ocular hypertension with normal visual fields (VFs) on repeated VF tests. PPG was defined as progression in the Guided Progression Analysis software from Cirrus-optical coherence tomography (GPA-OCT). Three PPG types were defined according to the GPA-OCT software as follows: (1) GPA-OCT with one or more red boxes in two or more columns; (2) GPA-OCT with two or more red boxes in two or more columns; and (3) GPA-OCT with two or more red boxes in two or more columns (definition 2), and in the last scan one or more red box in the RNFL average or quadrants. Nonparametric tests, areas under the receiver operating characteristic curve (AUC), and Bland-Altman tests were assessed.

Results:

Definitions one, two, and three were met by 44 (16.6%), 29 (10.9%), and 11 (4.2%) eyes, respectively. The GDC indices (means ± standard deviations) were, respectively, 14.49 ± 21.55% and 26.06 ± 22.50% using the combined and quantitative GDC (P < 0.001) in all eyes. Both GDC showed higher glaucoma probability in the PPG group (P < 0.04; combined GDC AUCs, 0.720-0.833; quantitative GDC AUCs, 0.700-0.839). GDC values were higher (P < 0.01) with greater GPA progression.

Conclusions:

The values of both GDC were higher in the PPG group than the ocular hypertension group. The GDC were higher when more columns in the GPA software indicated progression. Both GDC showed a similar ability to detect PPG.

Translational Relevance:

These calculators facilitate diagnosis of PPG in ocular hypertensive eyes.

KEYWORDS:

OCT; glaucoma diagnosis; glaucoma diagnostic calculator; optic disk; preperimetric glaucoma; retinal ganglion cell; retinal nerve fiber layer

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