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J Cancer. 2018 Oct 18;9(22):4179-4186. doi: 10.7150/jca.27483. eCollection 2018.

Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis.

Wang W1,2, Hu S1,2, Chang J1,2, Ruan H1,2, Zhi W1,2, Wang X1,2, Shi Q1,2, Wang Y1,2, Yang Y1,2.

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Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032China.
Key laboratory of theory and therapy of muscles and bones, Ministry of Education, Shanghai200032, China.


Background: In children and adolescents, osteosarcomais the most common malignant bone tumor with a high mortality rate. New therapeutic strategies are urgent to be explored. Studies have proven that microRNAs (miRNAs) in malignant tumors often appear dysregulation, this provides a direction for exploring the new therapeutic strategies for cancers. The aim of this meta-analysis is to summarize and analyze whethermicroRNA-34a(miRNA-34a) could be a prognostic marker for osteosarcoma in mice. Methods: We searched PubMed, Web of Science, Embase, Wan Fang Database, China Knowledge Resource Integrated Database, VIP Database, and SinoMed since their initiation date to January 24, 2018. After screening based on inclusion and exclusion criteria, eight articles were included for the final analysis. Results: Our results showed that tumor volume and tumor weight were inhibited by restoring the down-regulated expression of miRNA-34a in the xenograft mouse models. Conclusions: Down-regulated miRNA-34a expression is a prognostic marker for poor osteosarcoma. We should be more committed to investigate the clinical significance of miRNA-34a in osteosarcoma patients.


meta-analysis; mice; microRNA-34a; osteosarcoma; prognosis

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

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