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Front Physiol. 2018 Nov 21;9:1638. doi: 10.3389/fphys.2018.01638. eCollection 2018.

ABPS: An R Package for Calculating the Abnormal Blood Profile Score.

Author information

1
Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
2
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

Abstract

The Abnormal Blood Profile Score (ABPS) is used to identify blood doping in sport. It combines seven hematological markers, including hemoglobin level, reticulocytes percent, and haematocrit level, using two different machine learning algorithms in order to create a single score that has a better ability to identify doping than each parameter taken alone. The resulting score allows the detection of several types of doping using a single score and is part of the current Athlete Biological Passport program managed by World Anti-Doping Agency (WADA). We describe ≪ ABPS ≫, an R package that allows the calculation of this score. This is the first software implementation calculating this score that is released publicly. The package also contains functions to calculate the OFF-score (another score used for detection of doping), as well as several test datasets. The package is useful for laboratories conducting anti-doping analyses and for researchers working on anti-doping research projects. In particular, it has been successfully used in projects estimating the prevalence of blood doping.

KEYWORDS:

ABPS; anti-doping; blood doping; code:R; machine learning

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