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Nat Struct Mol Biol. 2018 Dec;25(12):1077-1085. doi: 10.1038/s41594-018-0164-z. Epub 2018 Dec 5.

Structural and molecular mechanisms for the control of eukaryotic 5'-3' mRNA decay.

Author information

1
Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
2
The Center for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, OH, USA.
3
Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA. jdgross@cgl.ucsf.edu.

Abstract

5'-3' RNA decay pathways are critical for quality control and regulation of gene expression. Structural and biochemical studies have provided insights into the key nucleases that carry out deadenylation, decapping, and exonucleolysis during 5'-3' decay, but detailed understanding of how these activities are coordinated is only beginning to emerge. Here we review recent mechanistic insights into the control of 5'-3' RNA decay, including coupling between translation and decay, coordination between the complexes and activities that process 5' and 3' RNA termini, conformational control of enzymatic activity, liquid phase separation, and RNA modifications.

PMID:
30518847
DOI:
10.1038/s41594-018-0164-z
[Indexed for MEDLINE]

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