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Dig Dis. 2019;37(3):214-225. doi: 10.1159/000494454. Epub 2018 Dec 5.

Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma.

Author information

1
Department of Gastroenterology, Translational Gastroenterology Laboratory, Shandong University, Qilu Hospital, Shandong, China.
2
Department of Endoscopy, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Shandong, China.
3
Department of Pathology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Shandong, China.
4
Department of Gastroenterology, Translational Gastroenterology Laboratory, Shandong University, Qilu Hospital, Shandong, China, liyanqing@sdu.edu.cn.

Abstract

Fibroblast growth factor 19 (FGF19) promotes tumor growth in various types of cancer, but its function has not been investigated in the context of colorectal adenoma. Here, we report that FGF19 expression was greater in colorectal adenoma than in normal tissues, as measured by an enzyme-linked immunosorbent assay, quantitative reverse-transcription PCR and immunohistochemistry. FGF19 expression was also elevated in a subset of human colon cancer cell lines. Moreover, FGF receptor 4 (FGFR4), the cognate receptor for FGF19, was upregulated in colorectal adenoma tissues. Lipid levels and body mass index values strongly correlated with FGF19 and FGFR4 levels in patients with colon adenomas. These observations indicate that the FGF19/FGFR4 pathway may be involved in the development of neoplasia, and that FGF19 may be a valuable diagnostic marker for the identification of patients with colorectal adenomas.

KEYWORDS:

Biological marker; Colorectal adenoma; Colorectal cancer; Fibroblast growth factor 19; Fibroblast growth factor receptor 4

PMID:
30517925
DOI:
10.1159/000494454
[Indexed for MEDLINE]

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