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Structure. 2018 Dec 4;26(12):1567-1570. doi: 10.1016/j.str.2018.11.010.

Guiding COMPASS: Dpy-30 Positions SET1/MLL Epigenetic Signaling.

Author information

1
Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
2
Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. Electronic address: cheryl.arrowsmith@uhnresearch.ca.

Abstract

In this issue of Structure, Haddad et al. (2018) solve the high-resolution trimeric crystal structure of human COMPASS-like components Dpy-30 and Ash2L (2:1) to unravel an uncharacterized interaction surface required for competent H3K4 methylation in cells and clarify Dpy-30's role in the allosteric regulation of KMT2 enzymes.

PMID:
30517884
DOI:
10.1016/j.str.2018.11.010

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