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Rev Soc Bras Med Trop. 2018 Nov-Dec;51(6):849-853. doi: 10.1590/0037-8682-0499-2017.

Antiprotozoal action of synthetic cinnamic acid analogs.

Author information

1
Plataforma de Bioensaios em Malária e Leishmaniose, Fundação Oswaldo Cruz, Porto Velho, RO, Brasil.
2
Programa de Pós-graduação em Biologia Experimental, Universidade Federal de Rondônia, Porto Velho, RO, Brasil.
3
Centro de Estudos de Biomoléculas Aplicadas à Saúde, Universidade Federal de Rondônia, Porto Velho, RO, Brasil.
4
Centro Universitário São Lucas, Porto Velho, RO, Brasil.
5
Centro para el Desarrollo de Investigación Científica, Asunción, Paraguay.
6
Instituto Nacional de Epidemiologia na Amazônia Ocidental, Porto Velho, RO, Brasil.

Abstract

INTRODUCTION:

Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds.

METHODS:

In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined.

RESULTS:

Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed.

CONCLUSIONS:

Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.

PMID:
30517542
DOI:
10.1590/0037-8682-0499-2017
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