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Acta Cir Bras. 2018 Nov;33(11):1037-1042. doi: 10.1590/s0102-865020180110000010.

The cardiopulmonary bypass and cancer dissemination puzzle1.

Author information

1
PhD, Full Professor, Division of Thoracic and Cardiovascular Surgery, Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo (FMRP-USP), Ribeirao Preto-SP, Brazil. Conception and design of the study, manuscript writing, critical revision.
2
Fellow Master degree, Experimental Medicine Program, Division of Thoracic and Cardiovascular Surgery, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Acquisition of data.
3
Fellow PhD degree, Experimental Medicine Program, Division of Thoracic and Cardiovascular Surgery, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Acquisition of data.
4
PhD, Assistant Professor, Department of Surgery and Anatomy, Division of Digestive Surgery, FMRP-USP, Ribeirao Preto-SP, Brazil. Acquisition of data.
5
Full Professor, Surgery and Anatomy Department, FMRP-USP, Ribeirao Preto-SP, and Department of Gastroenterology, Medical School, USP, Sao Paulo-SP, Brazil. Critical revision.

Abstract

Early cancer diagnosis, new therapies that increased survival of patients, besides the increasingly elderly population are some factors would be associated with possible cancer dissemination in patients under cardiopulmonary bypass (CPB) cardiac surgery. Also, the benefits, and risks, regarding long-term survival, have not yet been established. Therefore, cardiac surgery morbimortality may be superior in patients with cancer disease. Also, immunologic and inflammatory changes secondary to CPB can also increase tumor recurrence. After a brief introduction and CPB immunologic the two main topic subjects included: 1) Combined heart surgery and lung resection and; 2) Possible influence of neoplasia type. After observing the relative literature scarcity, we keep the opinion that "CPB has a modest association with cancer progression" and that "CPB and cancer dissemination should be a logical but unlikely association."

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