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Acta Cir Bras. 2018 Nov;33(11):954-963. doi: 10.1590/s0102-865020180110000002.

Prevention of rocuronium induced mast cell activation with prophylactic oleuropein rich diet in anesthetized rabbits1.

Author information

1
Assistant Professor, Department of Anesthesiology and Reanimation, Medical Faculty, Canakkale Onsekiz Mart University, Turkey. Design of the study, acquisition of data, manuscript preparation.
2
Associate Professor, Department of Anesthesiology and Reanimation, Medical Faculty, Canakkale Onsekiz Mart University, Turkey. Conception and design of the study.
3
Assistant Professor, Department of Histology, Canakkale Onsekiz Mart University, Turkey. Histopathological examinations.
4
Associate Professor, Department of Food Engineering, Engineering Faculty, Canakkale Onsekiz Mart University, Turkey. Interpretation of data, technical procedures.
5
Assistant Professor, Department of Anesthesiology and Reanimation, Medical Faculty, Canakkale Onsekiz Mart University, Turkey. Acquisition and interpretation of data.
6
Assistant Professor, Department of Anesthesiology and Reanimation, Medical Faculty, Canakkale Onsekiz Mart University, Turkey. Analysis and interpretation of data.

Abstract

PURPOSE:

The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study.

METHODS:

14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals' water at doses of 20 mg/kg oleuropein for 15 days orally. After 15 days, all rabbits in the two groups were given general anesthesia with rocuronium of 1 mg/kg. After 1 day, animals were sacrificed and the liver tissue sections stained with H&E, toluidine blue and tryptase for immunohistochemical study.

RESULTS:

There was no statistically significant difference between ALT, AST and albumin averages of the oleuropein and control groups (p> 0.05). The tryptase average of the control group was higher than the tryptase average of the oleuropein group and this difference was statistically significant (p=0.003). The T. blue average in the oleuropein group was higher than the control group. However, there was no statistically significant difference between groups (p=0.482).

CONCLUSIONS:

Rocuronium adverse effects, like hypersensitivity and anaphylaxis, may limit routine use of this substance. The use of oleuropein reduced the number of inflammatory cells and prevented degranulation.

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