Recurrent natural killer/T-cell lymphoma of the lacrimal sac and nasolacrimal duct in a 59-year-old Caucasian woman

Orbit. 2019 Oct;38(5):428-431. doi: 10.1080/01676830.2018.1546750. Epub 2018 Dec 5.

Abstract

A 59-year-old Caucasian woman with past medical history significant for Natural Killer (NK)/T-cell lymphoma of the right nasal septum in remission for nine months presented after surveillance PET-CT imaging revealed increased metabolic activity in the right nasolacrimal duct. She also reported ipsilateral epiphora starting around this time. The lacrimal sac and nasolacrimal ductal mucosa were biopsied via an external approach. Pathologic evaluation revealed a proliferation of lymphoid cells with necrotic tissue. Immunohistochemical staining demonstrated predominantly CD3+, EBER+, and CD56+ cells indicating recurrent NK/T-cell lymphoma. This case describes an unusual presentation of recurrent NK/T-cell lymphoma involving the lacrimal excretory system in a Caucasian adult. Recurrent malignancy should be considered in the differential of any patient with a history of a lymphoproliferative disorder near the lacrimal drainage system who presents with new onset epiphora.

Keywords: Natural killer; T-cell; lacrimal; lymphoma; recurrent.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Eye Neoplasms / diagnostic imaging
  • Eye Neoplasms / pathology*
  • Female
  • Humans
  • Lacrimal Apparatus Diseases / diagnostic imaging
  • Lacrimal Apparatus Diseases / pathology*
  • Lymphoma, Extranodal NK-T-Cell / diagnostic imaging
  • Lymphoma, Extranodal NK-T-Cell / pathology*
  • Lymphoma, Extranodal NK-T-Cell / surgery
  • Magnetic Resonance Imaging
  • Middle Aged
  • Nasolacrimal Duct / diagnostic imaging
  • Nasolacrimal Duct / pathology*
  • Neoplasm Proteins / metabolism
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / pathology*
  • Positron-Emission Tomography

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins