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Open Forum Infect Dis. 2018 Oct 24;5(11):ofy275. doi: 10.1093/ofid/ofy275. eCollection 2018 Nov.

Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity.

Author information

1
Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
2
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Abstract

Although the use of tenofovir alafenamide (TAF), a new prodrug of tenofovir, was safe and efficacious in clinical trials, real-world data from multimorbid individuals are scarce. Among 10 persons living with HIV with previous tenofovir disoproxil fumarate-induced nephrotoxicity, renal function remained stable, and proteinuria decreased in several patients after the switch to TAF.

KEYWORDS:

antiretroviral therapy; chronic kidney disease; drug nephrotoxicity; tenofovir alafenamide

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