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Biosci Rep. 2019 Jan 3;39(1). pii: BSR20181767. doi: 10.1042/BSR20181767. Print 2019 Jan 31.

AMPK: a therapeutic target of heart failure-not only metabolism regulation.

Li X1, Liu J1,2, Lu Q1,3, Ren D1, Sun X1,4, Rousselle T1, Tan Y5,6, Li J7.

Author information

1
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
2
Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, China.
3
Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu 610041, China.
4
Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang, China.
5
Pediatic Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, U.S.A.
6
Wendy L. Novak Diabetes Care Center, University of Louisville, Louisville, KY, U.S.A.
7
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A. jli3@umc.edu.

Abstract

Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has continued to increase over the past decade. All cardiovascular diseases causing dysfunction of various physiological processes can result in HF. AMP-activated protein kinase (AMPK), an energy sensor, has pleiotropic cardioprotective effects and plays a critical role in the progression of HF. In this review, we highlight that AMPK can not only improve the energy supply in the failing heart by promoting ATP production, but can also regulate several important physiological processes to restore heart function. In addition, we discuss some aspects of some potential clinical drugs which have effects on AMPK activation and may have value in treating HF. More studies, especially clinical trials, should be done to evaluate manipulation of AMPK activation as a potential means of treating HF.

KEYWORDS:

AMPK; heart failure; substrate metabolism

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