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Sci Signal. 2018 Dec 4;11(559). pii: eaav3530. doi: 10.1126/scisignal.aav3530.

A division of labor in mTORC1 signaling and autophagy.

Author information

1
Department of Biochemistry, Cell Biology and Max F. Perutz Laboratories, Vienna BioCenter, University of Vienna, Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria. Email: sascha.martens@univie.ac.at.

Abstract

In human cells, the p62 protein acts as an adaptor in various signaling pathways as well as a receptor for selective autophagy. In this issue of Science Signaling, Sanchez-Garrido et al show that proteolytic cleavage of p62 by caspase-8 determines whether p62 functions as an mTORC1 signaling adaptor or autophagy receptor.

PMID:
30514809
DOI:
10.1126/scisignal.aav3530

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