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Clin Cancer Res. 2018 Dec 4. pii: clincanres.3513.2018. doi: 10.1158/1078-0432.CCR-18-3513. [Epub ahead of print]

The Molecular Profiling Lottery: More Accuracy, Less Precision, and No Cost.

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Department of Medicine, Committee on Clinical Pharmacology and Pharmacogenomics, Cancer Research Center, University of Chicago


The concept of complete molecular profiling to select investigational treatment options is appealing; theoretically allowing the matching of patients to investigational drugs specifically targeted to molecular features of each patient's cancer. While some patients do benefit from such a strategy, the vast majority do not.

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