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Nutrients. 2018 Dec 3;10(12). pii: E1899. doi: 10.3390/nu10121899.

Supplementation of Juçara Berry (Euterpe edulis Mart.) Modulates Epigenetic Markers in Monocytes from Obese Adults: A Double-Blind Randomized Trial.

Author information

1
Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos 11015-020, Brazil. alinesantamarina@gmail.com.
2
Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos 11015-020, Brazil. gi.jamar@gmail.com.
3
Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos 11015-020, Brazil. laisvmennitti@hotmail.com.
4
Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos 11015-020, Brazil. helenacesarbr@gmail.com.
5
Departamento de Biociências, Universidade Federal de São Paulo, Santos 11015-020, Brazil. veriderosso@yahoo.com.
6
Departamento de Biociências, Universidade Federal de São Paulo, Santos 11015-020, Brazil. jrcvasconcelos@gmail.com.
7
Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil. lmoyama@gmail.com.
8
Departamento de Biociências, Universidade Federal de São Paulo, Santos 11015-020, Brazil. lucianapisani@gmail.com.
9
Laboratório de Nutrição e Fisiologia Endócrina (LaNFE), Departamento de Biociências, Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Rua Silva Jardim, 136, Térreo, Vila Mathias, Santos, São Paulo 11015-020, Brazil. lucianapisani@gmail.com.

Abstract

Nutrigenomics is an emerging field in obesity since epigenetic markers can be modified by environmental factors including diet. Considering juçara composition-rich in anthocyanins, monounsaturated fatty acids (MUFAs) and fibers-it has the potential for epigenetic modulation. We evaluated the juçara supplementation modulating the serum fatty acids profile and epigenetic markers in monocytes of adult obese humans. It was a randomized double-blind, controlled trial with 27 obese (Body mass index between 30.0 and 39.9 kg/m²) participants of both genders aged from 31 to 59 years, divided into juçara group (5 g juçara freeze-dried pulp) or placebo group (5 g of maltodextrin) for 6 weeks. Before and after supplementation, blood samples were collected. The serum and monocytes cells obtained were cultured and stimulated with lipopolysaccharides as proinflammatory stimulus. After 24 h of incubation, the cells and supernatants were collected and analyzed. Juçara improved the serum fatty acids profile on unsaturated fatty acids levels. The epigenetic markers evaluated were improved post-treatment. Also, the methylated DNA level was increased after treatment. We find that juçara supplementation is a predictor of methyl CpG binding proteins 2 (MeCP2) in monocytes. Concluding, juçara supplementation improved the serum fatty acids profile, modulating the epigenetic markers in monocytes from obese individuals.

KEYWORDS:

epigenetics; fatty acids; juçara; monocytes; monounsaturated fatty acid; obesity

PMID:
30513988
PMCID:
PMC6315800
DOI:
10.3390/nu10121899
[Indexed for MEDLINE]
Free PMC Article

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