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Nutrients. 2018 Dec 3;10(12). pii: E1897. doi: 10.3390/nu10121897.

Contrasting Effects of Short-Term Mediterranean and Vegan Diets on Microvascular Function and Cholesterol in Younger Adults: A Comparative Pilot Study.

Author information

1
Academy of Sport and Physical Activity, Sheffield Hallam University, Sheffield S10 2BP, UK. d.rogerson@shu.ac.uk.
2
The University of Sheffield, Sheffield S10 2RX, UK. dfjmacas1@sheffield.ac.uk.
3
The University of Sheffield, Sheffield S10 2RX, UK. marrianebmilner@gmail.com.
4
The University of Sheffield, Sheffield S10 2RX, UK. liuyingshan_sylvia@hotmail.com.
5
Centre for Sport and Exercise Sciences, Sheffield Hallam University, Sheffield S10 2BP, UK. m.klonizakis@shu.ac.uk.

Abstract

The Mediterranean diet has been shown to improve cardiovascular health. Vegan diets have demonstrated similar benefits, albeit in fewer studies. In a comparative pilot study, we compared the effects of a short-term Mediterranean Diet (MD) and Vegan Diet (VD) on microvascular function and cholesterol levels in a healthy population. Twenty-four young (aged 18 to 35 years) healthy volunteers followed a four-week intervention (MD = 12; VD = 12) ad libitum. Pre and post-intervention anthropometrics, microvascular function (assessed via LDF and expressed as raw CVC and %CVC MAX), dietary-analysis data (Calories, Protein, Carbohydrates, Total Fat, Saturated Fat, Fibre), Mean Arterial Pressure (MAP), Blood Pressure, Total Cholesterol (TC), High Density Lipoprotein (HDL-C) and TC:HDL-C were compared. MD participants reduced Total Fat intake (p = 0.05). Saturated Fat decreased (MD: p = < 0.001; VD: p = 0.004) and Fibre increased (MD: p = 0.02; VD: p = < 0.001) in both groups. Dietary changes reflected improvements in plateau raw CVC in the MD group (p = 0.005), and a reduction in TC (p = 0.045) and weight loss (p = 0.047) in the VD group. The MD led to improvements in microvascular function; the VD led to reduced TC and weight loss. Although both diets might offer CVD risk-reduction benefits, evidence for the MD appeared to be stronger due to changes in vasodilatory ability and NO bioavailability.

KEYWORDS:

cardiovascular disease; cholesterol; laser doppler flowmetry; mediterranean diet; microvascular function; vegan diet

PMID:
30513972
PMCID:
PMC6316028
DOI:
10.3390/nu10121897
[Indexed for MEDLINE]
Free PMC Article

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