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Nutrients. 2018 Dec 3;10(12). pii: E1892. doi: 10.3390/nu10121892.

Health Effects of Resveratrol: Results from Human Intervention Trials.

Author information

1
Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences XaRTA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain. sonialrmz@gmail.com.
2
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. sonialrmz@gmail.com.
3
Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences XaRTA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain. elaversa21@alumnes.ub.edu.
4
Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences XaRTA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain. mmarhuendam@ub.edu.
5
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. mmarhuendam@ub.edu.
6
Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences XaRTA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain. carolina.e.storniolo@gmail.com.
7
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. carolina.e.storniolo@gmail.com.
8
Human Nutrition Unit, University Hospital of Sant Joan de Reus, Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Center, University Rovira i Virgili, 43201 Reus, Tarragona, Spain. anna.tresserra@iispv.cat.
9
Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences XaRTA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain. avallverdu@ub.edu.
10
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. avallverdu@ub.edu.
11
Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences XaRTA, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain. lamuela@ub.edu.
12
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. lamuela@ub.edu.

Abstract

The effect of resveratrol (RV) intake has been reviewed in several studies performed in humans with different health status. The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and feces. The topics covered include RV bioavailability, pharmacokinetics, effects on cardiovascular diseases, cognitive diseases, cancer, type 2 diabetes (T2D), oxidative stress, and inflammation states. The overview of the recent research reveals a clear tendency to identify RV in plasma, showing that its supplementation is safe. Furthermore, RV bioavailability depends on several factors such as dose, associated food matrix, or time of ingestion. Notably, enterohepatic recirculation of RV has been observed, and RV is largely excreted in the urine within the first four hours after consumption. Much of the research on RV in the last 10 years has focused on its effects on pathologies related to oxidative stress, inflammatory biomarkers, T2D, cardiovascular diseases, and neurological diseases.

KEYWORDS:

antioxidant; bioavailability; metabolic diseases; obesity

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