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Alcohol. 2018 May 31;75:89-97. doi: 10.1016/j.alcohol.2018.05.010. [Epub ahead of print]

Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults.

Author information

1
Department of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland; Doctoral Programme of Clinical Research, School of Medicine, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland. Electronic address: noora.heikkinen@uef.fi.
2
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Niuvankuja 65, 70240 Kuopio, Finland.
3
Department of Adolescent Psychiatry, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland; Department of Psychiatry, School of Medicine, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland.
4
Department of Adolescent Psychiatry, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
5
Doctoral Programme of Clinical Research, School of Medicine, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland; Department of Adolescent Psychiatry, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
6
Doctoral Programme of Clinical Research, School of Medicine, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland.
7
Department of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
8
Metabolomics Unit, Institute for Molecular Medicine Finland FIMM, University of Helsinki, Tukholmankatu 8, 00270 Helsinki, Finland.
9
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland; Institute of Clinical Medicine, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland; Department of Psychiatry, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
10
Department of Applied Physics, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland.
11
Department of Clinical Radiology, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
12
Department of Psychiatry, School of Medicine, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.

Abstract

Our aim was to analyze metabolite profile changes in serum associated with moderate-to-heavy consumption of alcohol in young adults and to evaluate whether these changes are connected to reduced brain gray matter volumes. These study population consisted of young adults with a 10-year history of moderate-to-heavy alcohol consumption (n = 35) and light-drinking controls (n = 27). We used the targeted liquid chromatography mass spectrometry method to measure concentrations of metabolites in serum, and 3.0 T magnetic resonance imaging to assess brain gray matter volumes. Alterations in amino acid and energy metabolism were observed in the moderate-to-heavy drinking young adults when compared to the controls. After correction for multiple testing, the group of moderate-to-heavy drinking young adults had increased serum concentrations of 1-methylhistamine (p = 0.001, d = 0.82) when compared to the controls. Furthermore, concentrations of 1-methylhistamine (r = -0.48, p = 0.004) and creatine (r = -0.52, p = 0.001) were negatively correlated with the brain gray matter volumes in the females. Overall, our results show association between moderate-to-heavy use of alcohol and altered metabolite profile in young adults as well as suggesting that some of these changes could be associated with the reduced brain gray matter volume.

KEYWORDS:

Adolescence; Alcohol; Brain; MRI; Morphometry

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