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J Nutr Biochem. 2019 Feb;64:162-169. doi: 10.1016/j.jnutbio.2018.10.012. Epub 2018 Nov 7.

Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia.

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Research Laboratory of Pharmacology, Hospital Infántil de México Federico Gómez (HIMFG), Mexico.
Department of Allergy, HIMFG, Mexico City, Mexico. Electronic address:
Department of Allergy, HIMFG, Mexico City, Mexico.
Laboratory Center, HIMFG, Mexico City, Mexico.
Department of Environmental Health, Population Health Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
Research Laboratory of Pharmacology, Hospital Infántil de México Federico Gómez (HIMFG), Mexico; Laboratory of Pharmacology, Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University of Iztapalapa, Mexico City, Mexico.
Departamento de Inmunologıa, Instituto Nacional de Cardiología "Ignacio Chavez", Mexico City, Mexico.
Superior School of Medicine, National Polytechnic Institute, Mexico City, Mexico.
Sección de Estudios de Posgrado e Investigación, Escuela Nacional de Medicina y Homeopatía del Instituto Politécnico Nacional, Mexico City, Mexico.
Department of Pharmacobiology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.


Obesity in adolescents is considered a major public health problem; combined interventional approaches such as omega-3 supplementation with lifestyle intervention (LI) might exert synergistic effects and exceed the impact of each individual strategy. The purpose of the present study was to evaluate if the supplementation of omega-3 with LI could improve metabolic and endothelial abnormality in obese adolescents with hypertriglyceridemia. The study involved sixty-nine adolescents with normal weight and seventy obese adolescents with hypertriglyceridemia. All obese adolescents were applied to LI and randomly assigned to omega-3 supplementation or placebo group for 12 weeks. The obese adolescents with hypertriglyceridemia presented increased levels of leptin, retinol binding protein 4 (RBP4), selectin E (sE) and asymmetric dimethylarginine (ADMA) and decreased levels of adiponectin compared with control subjects. After 12-week intervention, omega-3 supplementation with LI decreased significantly in triglycerides, HOMA, leptin, RBP4, ADMA and sE. Moreover, omega-3 with LI displayed a significant reduction in triglycerides, ADMA and sE in comparison with LI alone. In subjects with omega-3 combined with LI assessed by multivariate regression model, the reduction in triglycerides was the only independent determinant of the decrease in ADMA. The reductions in triglycerides and HOMA were significantly contributed to the changes in sE. Our data indicated that omega-3 combined with LI in short duration significantly improved dyslipidemia, insulin resistance, abnormality of adipokines, endothelial dysfunction in comparison of LI alone, indicating the combined approach is an effective clinical and applicable strategy to control metabolic abnormality and decrease the risks of cardiovascular diseases in obese adolescents.


ADMA; Adipokines; Lifestyle intervention; Obese adolescents; Omega-3; sE

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