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Dev Cell. 2018 Dec 3;47(5):541-542. doi: 10.1016/j.devcel.2018.11.020.

Orchestrating Nuclear Envelope Sealing during Mitosis.

Author information

1
Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
2
Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway. Electronic address: stenmark@ulrik.uio.no.

Abstract

Sealing of the nascent nuclear envelope during mitotic exit is mediated by the polymeric ESCRT-III protein machinery. In this issue of Developmental Cell, Ventimiglia et al. (2018) identify the ESCRT-III-associated protein CC2D1B as a lipid-binding coordinator of late-mitotic ESCRT-III assembly and disassembly of the mitotic spindle.

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