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Cutan Ocul Toxicol. 2018 Dec 4:1-23. doi: 10.1080/15569527.2018.1554667. [Epub ahead of print]

(3R, 3'R)-Zeaxanthin protects the retina from photo-oxidative damage via modulating the inflammation and visual health molecular markers.

Author information

1
a Department of Animal Nutrition, Faculty of Veterinary Science , Firat University , Elazig , Turkey ;
2
b Department of Nutrition, Faculty of Fisheries , Inonu University , Malatya , Turkey ;
3
c Division of Biology, Faculty of Science , Firat University , Elazig , Turkey ;
4
d Department of Pathology, Faculty of Medicine , Firat University , Elazig , Turkey ;
5
e Department of Biochemistry, Faculty of Science , Jamia Hamdard , New Delhi , India ;
6
f Department of Pharmacology, Faculty of Pharmacy , Inonu University , Malatya , Turkey ;
7
g Research and Development , OmniActive Health Technologies Inc. , Morristown , NJ , USA.

Abstract

PURPOSE:

Zeaxanthin protects the macula from ocular damage due to light or radiation by scavenging harmful reactive oxygen species. In the present study, zeaxanthin product (OmniXan®; OMX), derived from paprika pods (Capsicum annum; Family-Solanaceae), was tested for its efficacy in the rat retina against photooxidation.

METHODS:

Forty-two male 8-week-old Wistar rats exposed to 12L/12D, 16L/8D and 24L/0D hours of intense light conditions were orally administrated either 0 or 100 mg/kg BW of zeaxanthin concentration. Retinal morphology was analyzed by histopathology, and target gene expressions were detected with real-time polymerase chain reaction methods.

RESULTS:

OMX treatment significantly increased the serum zeaxanthin concentration (P < 0.001) and ameliorated oxidative damage by increasing the antioxidant enzyme activities in the retina induced by light (P < 0.001). OMX administration significantly upregulated the expression of genes, including Rhodopsin (Rho), Rod arrestin (SAG), Gα Transducin 1 (GNAT-1), neural cell adhesion molecule (NCAM), growth-associated protein 43 (GAP43), nuclear factor-(erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase (HO-1) and decreased the expression of nuclear factor-κB (NF- κB) and GFAP by OMX treatment rats. The histologic findings confirmed the antioxidant and gene expression data.

CONCLUSIONS:

This study suggests that OMX is a potent substance that can be used to protect photoreceptor cell degeneration in the retina exposed to intense light.

KEYWORDS:

Light-emitting diode (LED); oxidative stress; photo-oxidation; retina; zeaxanthin

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