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Diabetes Metab Res Rev. 2018 Dec 4:e3107. doi: 10.1002/dmrr.3107. [Epub ahead of print]

Exosomes and diabetes.

Author information

1
Diabetes and Obesity Research Laboratory, Institut dꞋInvestigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain.

Abstract

Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life-threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resistance in peripheral tissues such as liver, muscle or the adipose depots. Communication between organs is thus central to the maintenance of glucose homeostasis. Recently, several studies are evidencing that small vesicles called exosomes released by, amongst other, the adipose tissue, can regulate gene expression in other tissues, hence modulating inter-organ cross-talk. Therefore, exosomes participate in the development of diabetes and its associated complications. Their study holds the potential of providing us with novel biomarkers for the early diagnosis and stratification of patients at risk of developing diabetes, hence allowing the timely implementation of more personalized therapies. On the other hand, the molecular dissection of the pathways initiated by exosomes under situations of metabolic stress could help us to gain a deeper knowledge of the pathophysiology of diabetes and its associated metabolic diseases.

KEYWORDS:

cross-talk; diabetes; exosome; microRNA; obesity; therapy

PMID:
30513130
DOI:
10.1002/dmrr.3107

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