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J Genomics. 2018 Nov 15;6:122-126. doi: 10.7150/jgen.27741. eCollection 2018.

Genomic Analysis of Rhodococcus sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan.

Author information

1
Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.
2
Faculty of Environment and Information Studies, Keio University, Fujisawa, Kanagawa, Japan.
3
Center for Environmental Biology and Ecosystem Studies, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan.
4
Center for Regional Environmental Research, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan.
5
Graduate School of Horticulture, Chiba University, Matsudo City, Chiba, Japan.

Abstract

Bromate is a byproduct of the ozone disinfection of drinking water. It is a genotoxic carcinogen and causes renal cell tumors in rats. Physicochemical removal of bromate is very difficult, making microbial reduction of bromate to bromide a promising approach to eliminate bromate from water. Rhodococcus sp. Br-6, isolated from soil, can efficiently reduce bromate by using acetate as an electron donor. We determined the draft genome sequence of Rhodococcus sp. Br-6 for the potential practical application of the bromate-reducing bacterium. Core genome phylogeny suggests that the Br-6 strain is most closely related to R. equi. The Br-6 genome contains genes encoding multiple isoforms of diaphorase, previously found to be involved in Br-6-mediated bromate reduction. The genes identified in the present study could be effective targets for experimental studies of microbial bromate reduction in the future.

KEYWORDS:

Bromate reducing bacterium; Diaphorase.; Genome; Phylogeny; Rhodococcus sp. Br-6

Conflict of interest statement

Conflicts of Interest: The authors declare that there are no conflicts of interest.

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