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Nat Med. 2018 Dec 3. doi: 10.1038/s41591-018-0265-6. [Epub ahead of print]

Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.

Author information

1
Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
2
Department of Pathology, Aix-Marseille University, APHM, Hôpital de la Timone, Marseille, France.
3
Dermatology and Skin Cancer Department, Aix-Marseille University, APHM, Hôpital de la Timone, Marseille, France.
4
Medical Physics Department and The University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Salford, UK.
5
Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK. richard.marais@cruk.manchester.ac.uk.

Abstract

The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

PMID:
30510256
DOI:
10.1038/s41591-018-0265-6

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