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Biosci Rep. 2019 Jan 15;39(1). pii: BSR20181052. doi: 10.1042/BSR20181052. Print 2019 Jan 31.

A trial sequential meta-analysis of TNF-α -308G>A (rs800629) gene polymorphism and susceptibility to colorectal cancer.

Author information

1
Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
2
Department of Life and Environmental Sciences, College of Natural and Health Sciences, Zayed University, P.O. Box 19282, Dubai, United Arab Emirates.
3
School of Life Sciences, Manipal Academy of Higher Education, P.O. Box 345050, Dubai, United Arab Emirates.
4
Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha 65431, Saudi Arabia.
5
Centre for Life Sciences, Central University of Jharkhand, Ranchi 835205, Jharkhand, India.
6
Department of Emergency Medical Services, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia.
7
Department of Biotechnology, Institute of Engineering and Technology, Lucknow 226021, Uttar Pradesh, India.
8
Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia shafiul.haque@hotmail.com.

Abstract

PURPOSE:

Tumor necrosis factor-α (TNF-α), secreted by the activated macrophages, may participate in the onset and progression of colorectal cancer (CRC). The association of TNF-308 G>A (rs1800629) single-nucleotide polymorphism (SNP) with CRC risk has been investigated by many studies but the results are inconclusive. A trial sequential meta-analysis was performed for precise estimation of the relationship between TNF-308 G>A gene polymorphism with CRC risk.

METHODS:

Medline (PubMed), EMBASE (Excerpta-Medica) and Google Scholar were mined for relevant articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the significance of association.

RESULTS:

The pooled analysis indicated no risk associated with TNF-308 G>A SNP and overall CRC risk in five genetic comparison models, i.e. allelic (A vs. G: P = 0.524; OR = 1.074, 95% CI = 0.863-1.335), homozygous (AA vs. GG: P = 0.489; OR = 1.227, 95% CI = 0.688-2.188), heterozygous (AG vs. GG: P = 0.811; OR = 1.024, 95% CI = 0.843-1.244), dominant (AA+AG vs. GG: P = 0.630; OR = 1.055, 95% CI = 0.849-1.311) and recessive (AA vs. AG+GG: P = 0.549; OR = 1.181, 95% CI = 0.686-2.033). Subgroup analysis revealed that TNF-308 G>A SNP is associated with reduced risk of CRC in Asian ethnicity. The study showed no publication bias.

CONCLUSIONS:

No association of TNF-308 G>A SNP with overall CRC risk was found. This SNP is likely to be protective against CRC in Asian population when compared with Caucasian population. Larger prospective-epidemiological studies are warranted to elucidate the roles of TNF-α -308 G>A SNP in the etiology of CRC and to endorse the present findings.

KEYWORDS:

Colorectal cancer; Meta-analysis; Tumor Necrosis Factor-α; polymorphism; susceptibility

PMID:
30509964
PMCID:
PMC6331670
DOI:
10.1042/BSR20181052
[Indexed for MEDLINE]
Free PMC Article

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