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J Occup Environ Med. 2019 Apr;61(4):271-277. doi: 10.1097/JOM.0000000000001511.

Arsenic Exposure and Incident Hypertension of Adult Residents Living in Rural Areas Along the Yangtze River, Anhui, China.

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Department of Epidemiology and Biostatistics, School of Public Health (Dr Zhong, Ms Zhang, Dr Zhang, Mr Jiang, Dr Liang, Dr Huang); Ma'anshan Center for Disease Control and Prevention, Ma'anshan (Dr Qin, Mr Chen); and Experimental Center Platform for Physical and Chemical (Dr Huang), Anhui Medical University, Hefei, Anhui, P.R. China.



As a widespread toxic metal, arsenic had potential effect for hypertensive. We evaluated the association between urinary arsenic and the incidence of hypertension in adult residents along the Yangtze River of China.


We conducted the study of 1358 adults 18 to 74 years of age from Chizhou, Maanshan, and Tongling of Anhui province, who participated in the baseline study in 2014 to 2015. Inductively coupled plasma optical emission spectrometry was used to measure urinary as of residents, and follow-up extended through 2016 to 2017.


We identified 275 hypertension events. The hazard ratios (HRs) of highest quartile arsenic compared with lowest quartile was 1.49 for hypertension events (95% confidence interval [CI] = 1.05 to 2.12), and HRs (≥P20 vs <P20) was 1.37 (95% CI = 1.02 to 1.84).


Higher level of arsenic exposure might play a role in increasing the incidence of hypertension.

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