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Congenit Heart Dis. 2019 Mar;14(2):274-279. doi: 10.1111/chd.12722. Epub 2018 Dec 2.

The effect of right ventricular function on survival and morbidity following stage 2 palliation: An analysis of the single ventricle reconstruction trial public data set.

Author information

1
Division of Cardiology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia.
2
Division of Translational Research and Statistics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.

Abstract

OBJECTIVE:

Limited information is known on how right ventricular function affects outcomes after stage 2 palliation. We evaluated the impact of different right ventricular indices prior to stage 2 palliation on morbidity and mortality.

DESIGN:

Retrospective study design.

SETTING:

Pediatric Heart Network Single Ventricle Reconstruction Trial Public Data Set.

PATIENT:

Any variant of stage 1 palliation and all anatomic hypoplastic left heart syndrome variants in the trial were evaluated. Echocardiograms prior to stage 2 palliation were analyzed and compared between those who failed and those who survived.

INTERVENTION:

None.

OUTCOME MEASURES:

Mortality was defined as death, listed for transplant, or transplanted after stage 2 palliation. Morbidity was evaluated as hospital length of stay and duration of intubation.

RESULTS:

A total of 283 patients met criteria for analysis. Of those, only 18 patients failed stage 2. Right ventricular fractional area change was less in those who failed (30% vs 34%, P = .039) and right ventricular indexed end-diastolic volume and end-systolic volume were larger in those who failed (142.74 mL/ BSA1.3 vs 111.29 mL/BSA1.3 , P = .023, 88.45 mL/ BSA1.3 vs 62.75 mL/ BSA1.3 , P = .025, respectively). Larger right ventricular indexed end-diastolic and systolic volumes were associated with failure (OR 1.17 [1.01-1.35] P = .021, OR 1.25 [1.03-1.52] P = .021, respectively). Every 10% increase in RV ejection fraction had a 63% decrease in length of stay and a 68% decrease in duration of intubation (P = .014, and P = .039, respectively).

CONCLUSION:

Patients with decreased right ventricular fractional area change and larger right ventricular indexed end-diastolic and systolic volumes were more likely to fail stage 2 palliation. Those with preserved right ventricular function had a shorter hospital length of stay and duration of intubation. Echocardiographic measurements of right ventricular indices during the interstage period can be utilized to determine the prognosis following stage 2 palliation.

KEYWORDS:

SVR; echocardiography; hypoplastic left heart syndrome; right ventricular function; stage 2 palliation

PMID:
30506893
DOI:
10.1111/chd.12722
[Indexed for MEDLINE]

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