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Arch Womens Ment Health. 2018 Dec 1. doi: 10.1007/s00737-018-0931-1. [Epub ahead of print]

Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression.

Author information

1
Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), University Rennes, UMR_S 1085, F-35000, Rennes, France. j.pawluski@gmail.com.
2
Department of Pediatrics, BC Children's Hospital, The University of British Columbia, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
3
Department of Cellular and Physiological Sciences, Faculty of Medicine, The University of British Columbia, Vancouver, Canada.

Abstract

The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation.

KEYWORDS:

Antidepressants; Anxiety; Depression; Gestation; Motherhood; Neuroplasticity

PMID:
30506371
DOI:
10.1007/s00737-018-0931-1

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