Format

Send to

Choose Destination
Sci Rep. 2018 Nov 30;8(1):17510. doi: 10.1038/s41598-018-35552-8.

Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee.

Author information

1
Department of Medical Imaging, The First Affiliated Hospital of Xi´an Jiaotong University, 277 West Yanta Road, Xi´an Shaanxi, 710061, P. R. China.
2
School of Public Health, Xi´an Jiaotong University Health Science Center, Xi´an, P. R. China.
3
Center for Machine Vision and Signal Analysis, Faculty of Information Technology and Electrical Engineering, University of Oulu, Oulu, Finland.
4
School of Public Health, Xi´an Jiaotong University Health Science Center, Xi´an, P. R. China. guox@mail.xjtu.edu.cn.
5
Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
6
Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
7
Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.
8
Department of Integrative Molecular Biology, Umeå University, 90187, Umeå, Sweden.
9
Department of Integrative Molecular Biology, Umeå University, 90187, Umeå, Sweden. chengjuan.qu@gmail.com.

Abstract

To compare tibial bone texture between Kashin-Beck disease (KBD) patients and normal individuals from plain radiographs using an advanced image analysis. Plain knee radiographs were obtained from KBD patients (n = 49) and age-matched healthy controls (n = 98). KBD were graded with diagnostic criteria WS/T 207-2010. The textural values related to bone structure from medial and lateral tibial subchondral and trabecular bones were evaluated using entropy of Laplacian-based image (ELap), entropy of local binary patterns (ELBP), homogeneity indices (HI) of local angles (HIMean, HIPerp and HIParal), and fractal dimensions from horizontal (FDHor) and vertical (FDVer) structures. KBD patients were shorter in height and lighter in weight, and their tibial width was wider than controls. Anatomical angle of KBD patients showed more genu valgus. Total KBD patients and subgroups had higher ELap, HIMean, HIPerp and HIParal in detected tibial subchondral and trabecular bones than controls, except ELap in lateral subchondral bone. ELBP, FDHor and FDVer from the detected tibial bone in KBD patients and subgroups were lower than controls, except FDVer in lateral trabecular bone. Our results indicate that micro-scale in bone texture in KBD-affected knees can be quantitatively examined from plain radiographs using an advanced image analysis.

PMID:
30504816
PMCID:
PMC6269488
DOI:
10.1038/s41598-018-35552-8
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center