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Anticancer Res. 2018 Dec;38(12):6783-6788. doi: 10.21873/anticanres.13049.

Relationship Between Preoperative Erythrocyte Sedimentation Rate and Survival After Surgery in Patients with Colorectal Cancer.

Author information

1
Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan norisuke_1983@hotmail.com.
2
Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan.

Abstract

AIM:

To investigate the relationship between erythrocyte sedimentation rate (ESR) and postoperative survival of patients with colorectal cancer (CRC).

MATERIALS AND METHODS:

Relationships between clinical characteristics and overall survival (OS) of patients with CRC were investigated using multivariate analysis. Receiver operating characteristics curve analysis was performed to decide the ideal cut-off values of clinical characteristics to divide patients into two groups, which were then compared using a survival curve analysis.

RESULTS:

Three hundred and eleven patients with CRC undergoing surgery were enrolled. Multivariate analysis showed that ESR >40 mm/h (hazard ratio(HR)=2.601, 95% confidence interval(CI)=1.187-5.697; p=0.017) was associated with poorer OS, along with non-tubular pathology (p=0.034). Kaplan-Meier analysis revealed that patients with ESR >40 mm/h had poorer postoperative survival than those without ESR elevation (p<0.001).

CONCLUSION:

Preoperative elevation of ESR (>40 mm/h) can predict poorer postoperative survival in patients with CRC.

KEYWORDS:

Colorectal cancer; erythrocyte sedimentation rate; inflammation-based prognostic system; systemic inflammatory response

PMID:
30504390
DOI:
10.21873/anticanres.13049
[Indexed for MEDLINE]

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